Coordinators :
Marie-Hélène Le Du
CEA Research Director at the I2BC, Gif-sur-YvetteScientific expertise: Structural biology, crystallography, small-angle scattering, telomere architecture
Other interests: Multimedia teaching: MOOCs, serious games, books, etc.
Coordinator of the MOOC ‘Voyage au coeur du vivant avec des rayons X : la cristallographie’.
Videos:
1/ What is a 3D structure?
2/ Structural biology methods
3/ Prerequisites : knowing your sample
4/ Clone, produce, purify your sample
5/ Crystal properties and Bragg’s law
6/ Light/matter interaction
7/ Introduction to Fourier transform
8/ Fourier transform and the phase problem
9/ Patterson function
10/ Model refinement, analysis and validation
11/ Animation Video : Journey into the proteins universe
Robert Schneider
CEA research scientist at the IBS, GrenobleScientific expertise: Structural biology, NMR spectroscopy, biophysics, membrane proteins, disordered proteins
Other interests: Multimedia teaching: MOOCs, etc.
Teaching team of the MOOC Nuclear Magnetic Resonance a Compass to Nanoword
Videos:
1/ Histoiry of NMR
2/ Local magnetic field
3/ Chemical shift
4/ NMR instrument
5/ 2D NMR experiment
Pierre-Damien Coureux
Faculty professor at the Université Claude Bernard Lyon 1Scientific expertise: Structural biology, Cryo Electron Microscopy, X-ray crystallography, translation regulation
Other interests: e-learning, teaching
Videos:
The complete team, in alphabetical order:
Karine Blondeau
Assistant Professor at the University Paris-SaclayDirector of the Continuing Education & VAE Department at the Orsay Faculty of Science
Research scientist at the Institute of Integrative Cell Biology I2BC
Head of the Prot-Ex research services platform
Scientific expertise: Microbial biotechnology, Industrial microbiology, Recombinant protein production
Other interests: Resuming studies, Validation of prior learning, DAEU, Continuing education
Videos: Preparation of biological samples :
1/ Which expression system for which project?
2/ Choosing the right expression system
Jean-Baptiste Charbonnier
CEA Research Director at the I2BC, Gif-sur-YvetteScientific expertise: Protein biochemistry, Macromolecule interactions, Structural biology, DNA repair
Other interests: Teaching
Videos:
1/ Mutations that cause illness
2/ Crystallisation: General principles
3/ Crystallisation: Approaches and platforms
4/ Crystallisation: A tour of the laboratory
Sonia Fieulaine
CNRS Research Scientist at the I2BC, Gif-sur-YvetteScientific expertise: Biochemistry, Structural biology, In vitro translation, RNA-positive viruses
Video:
In vitro protein production
Dominique Housset
CEA Research Director at the IBS, GrenobleScientific expertise: Crystallography, Electron diffraction, Structural biology, Biophysics
Other interests: Teaching
Videos : Correlation coefficient :
1/ Definition
2/ Applications
Bruno Kieffer
Professor at the Strasbourg School of BiotechnologyScientific expertise: NMR, Structural Biology
Other interests: Teaching
Videos: Introduction to NMR
1/ First part
2/ Second part
Pierre Legrand
Beamline manager on PROXIMA1, beamline dedicated to crystallography at the SOLEIL synchrotron, Saint Aubint AubinScientific expertise: Crystallography, Cryo-EM, Structural Biology.
Teaching team of the MOOC « Voyage au coeur du vivent avec des Rayons X : la cristallographie«
Videos :
1/ Processing diffraction data
2/ Analysis of diffraction data
Yves Méchulam
CNRS Research Director at BiocProfessor at the Ecole Polytechnique, Palaiseau
Scientific expertise: Mechanisms of mRNA translation into proteins, Crystallography, Cryo-electron microscopy, Biochemistry
Other interests: Teaching
Teaching team for the MOOC « Voyage au coeur du vivent avec des Rayons X : la cristallographie
Videos:
1/ Experimental phasing: Isomorphous replacement
2/ Experimental phasing: Anomalous scattering
3/ Molecular replacement
4/ Phase improvement and model building
Célia Plisson-Chastang
CNRS Research Director at CBI, ToulouseScientific expertise: Structural biology, Cryo-electron microscopy
Other interests: Teaching
Videos: Introduction to Cryo-EM coupled with image analysis :
First part
Second part
Sylvain Ravy
CNRS Research Director at Laboratoire de Physique des Solides from the University Paris-Saclay, OrsayScientific expertise: Crystallography, Disordered Systems, X-ray Diffusion
Other interests: Popular science, History of Science
Teaching team for the MOOC « Voyage au coeur du vivent avec des Rayons X : la cristallographie«
Videos:
1/ History of X-ray crystallography: the beginnings
2/ History of X-ray crystallography: the continuation
3/ The role of CCP4
Bruno Robert
CEA Research Director at the I2BC, Gif-sur-YvetteScientific expertise: Photosynthesis, Spectroscopy, Excited electronic states
Other areas of interest: Biology, Health and Agronomy infrastructures
Videos: From photosynthesis to bioenergy :
1/ Photosynthesis
2/ Toward bioenergy
Alain Roussel
CNRS Research Director at LISM, MarseilleScientific expertise: Crystallography, Structural biology
Videos:
A short history of computing
Introduction to LINUX
Serena Sirigu
Beamline scientist on PROXIMA2A, beamline dedicated to crystallography at the SOLEIL synchrotron, Saint Aubint AubinScientific expertise: Crystallography, Structural biology
Teaching team for the MOOC « Voyage au coeur du vivent avec des Rayons X : la cristallographie
Videos :
1/ How to generate X-rays
2/ Freezing crystals
3/ The crystal environment in the experimental cabin
4/ Data acquisition: the strategy for recording data
Gerlind Sulzenbacher
CNRS Research Engineer at the AFMB, MarseillScientific expertise: Crystallography, Structural biology, Glycobiology
Other interests: Disseminating scientific culture
Videos: Structural models :
1/ How to observe them
2/ Model quality evaluation
Carine Tellier-Lebègue
CEA technician at the ‘I2BC, Gif-sur-YvetteScientific expertise: Protein biochemistry, Expression and purification of recombinant proteins, Preparation of complex protein/RNA samples.
Videos:
1/ Crystallisation: General principles
2/Crystallisation: Approaches and platforms
3/ Crystallisation: Visit the laboratoty
4/ Sample preparation: Visit the laboratory
Aurélien Thureau
Beamline scientist on SWING, SAXS beamline of SOLEIL synchrotron, Saint-AubinScientific expertise: SAXS, Structural biology, NMR, Molecular modelling
Vidéo : Introduction to small angle X-ray scattering
Sophie Zinn-Justin
CEA Research Director at the I2BC, Gif-sur-YvetteScientific expertise: NMR, macromolecule interactions, structural biology, DNA repair
Other interests: Training (master’s/thesis, discovering research)
Videos: Mutations that cause illness
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